Barely Significant

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showed a trendp = 0.091.8× alpha
Although absolute numbers of circulating CD4 + T cells only showed a trend towards increased levels ( Figure 1a, p = 0.09), we observed a 2.3-fold increase in the proportion of activated CD44 hi CD62L − effector/memory cells among CD4 + T cells in blood of Ldlr −/− Pd1 −/− mice ( Figure 1b ).
near significancep = 0.091.8× alphagold
The cut-point for Spry2 expression were calculated as described in the Materials and Methods , such that as well as showing high significance for difference in survival (p = 0.0069; Figure 5B ), the cutpoint for Spry2 expression also maintained near significance with Monte Carlo simulations (p = 0.09) and correction for type I error (Miller-Seigmund p value = 0.12).