“nominally significant”

Nominally significant interactions between LR and HR groups were observed for correlations between YMRS total scores and left superior frontal surface area ( p = 0.002, uncorrected) (Fig. 4A ), CBCL total score and right lateral orbitofrontal surface area ( p = 0.005, uncorrected) (Fig. 4B ), and CBCL dysregulation subscale scores and right lateral orbitofrontal surface area (p = 0.008, uncorrected) (Fig. 4C ).

Although only nominally significant, as endpoints were exploratory, fewer patients experienced an eGFR decline of 30% (HR 0.68; 95% CI 0.58–0.79, P < 0.002), 40% (HR 0.54; 95% CI 0.43–0.67, P < 0.002) or 50% (HR 0.57; 95% CI 0.40–0.81, P < 0.002) to an eGFR < 60 mL/min/1.73 m 2 with dapagliflozin compared with placebo.

11 , 12 We observed a nominally significant association with TB risk in both our Chinese Han and Tibetan samples for rs557011 with a consistent direction of effect with reported results ( p = 0.002 and 0.009, respectively).

We observed a nominally significant association with 2 HLA alleles: HLA-A*23:01 (OR=1.04, p=2.3x10 -3 ) and HLA-C*06:02 (OR=1.04, p=1.5x10 -3 ).

Although this SNP was also found to be nominally significantly associated with the estimated plasma and effect-site MECs in the present study in the additive model (combined β = −0.07784, nominal p = 0.00232, for the 0–6 h plasma MEC; combined β = −0.07517, nominal p = 0.00310, for the 0–12 h plasma MEC; combined β = −0.09432, nominal p = 0.00250, for the 0–

All P -values were two-tailed; P < 0.05 was considered nominally significant, and P < 0.0026 (Bonferroni correction P = 0.05/19) was considered a significant association.

For tremor, the top scoring model from this subchallenge (yuanfang.gaun) showed only one nominally significant subject (1046, p-value = 0.003), and the cross-subject meta-analysis was not significant after multiple test correction (unadjusted p-value = 0.047).

Among which tryptophan betaine was the most significant causal metabolite in both AF GWAS data (from Nielsen et al.) (odds ratio (OR) = 0.83, 95% confidence interval (CI) = 0.76–0.90, P = 9.37 × 10 −6 ) and AF GWAS data (from Roselli et al.) (OR = 0.82, 95% CI = 0.76–0.88, P = 2.00 × 10 −7 ), while uridine was nominally significant metabolites in both AF GWAS data (from Nielsen et al.) (OR = 0.58, 95% CI = 0.40–0.84, P = 0.004) and AF GWAS data (from Roselli et al.) (OR = 0.56, 95% CI = 0.35–0.88, P = 0.01).

After performing multivariable logistic regression and retaining nominally significant variables, two and three vaccination shots remained significant, and their OR were 0.445 and 0.558 in the optimal model (Two shots: p = 0.004; Three shots: p = 0.017) ( Figure 1 ).

Examining nominally significant DEGs with a log fold-change (FC) exceeding 1.5 revealed four additional genes, including Depp1 (female-upregulated, logFC 2.3, p < 4 × 10 −3 ) and Avpr1b (female-upregulated, logFC 2.13, p < 2 × 10 −3 ).

However, the G-G haplotype of IRF6 was nominally significant with NSCL/P ( p = 0.0046) and is worthy of consideration for another independent replication study in the future.

Although the GO annotation term includes both positive and negative regulators of Wnt signaling, the pathway “negative regulation of canonical Wnt signaling” is also nominally significant for the biased downregulation of freshwater alleles (7/7 genes, Fisher's exact test, P = 0.0048), suggestive of the biased Wnt inhibition in marine fish ( figs. 3 D and E ).

Nominally significant associations between eyeAge and both COPD (p-value = 0.0048) and myocardial infarction (p-value = 0.049) were observed ( Supplementary file 3 ).

Power to establish whether a variant is a risk factor or not is low as there were only 1774 AA cases and accordingly only R161H in SDF2L1 was even nominally significant ( p = 0.005) in AA, yet all 8 risk alleles with European MAF > 0.01 are concordant in their observed direction of effect in AA and EA (contrast the heights of the dark and lighter-blue shades for AA, or dark and lighter reds for the two EA cohorts in Fig. 1 ).

However, we found the AL - BS haplotype was nominally significantly associated with C3 protein concentration ( b AL-BS = 0.23, SE = 0.03, p = 5.4 × 10 −3 ).

Metabolites Associated With DR We found 17 metabolites associated with DR without adjustment for confounding factors; 7 of them were statistically significant ( P < 5.0 × 10 −5 ) and 10 nominally significant ( P < .006) after the adjustment for confounding factors.

The radial glia-like cells (RGCs) in the subventricular zone (SVZ-RGCs, p = 0.0035), RGCs in the dentate gyrus (DG-RGCs, p = 0.0261), and oligodendrocytes (p = 0.0306) showed nominally significant enrichment in the cell-specific enrichment analysis ( Figure 4 B), of which DG-RGCs were also nominally significant (p = 0.0066–0.0484) in three robustness analyses ( Table S10 ).

Of the nominally significant modules, lightsteelblue (r = 0.63, p = 0.01) and darkviolet (r = −0.57, p = 0.03) were of the most interest.

A gain in ISG15 was nominally significantly associated with better recurrence-free survival (RFS) [HR (95% CI):0.40 (0.2–0.80), P = 0.010], disease-specific survival (DSS) [HR:0.30 (0.13–0.71), P = 0.006] and overall survival (OS) [HR:0.31 (0.14–0.69), P = 0.004], but not after correction for multiple testing.

The correction was done in two steps: first, we regressed the expression vector of each gene against covariates and selected those with nominally significant coefficients ( p < 0.01).

This interaction remained significant among men ( P = 6.1 × 10 −8 ) but was only nominally significant among women ( P = 0.01).

Linear regression analysis provided several nominally significant (p < 0.01) metabolic changes between the two groups in diabetic individuals ( Table 2 ).

A nominally significant result was found for the logistic regression (OCD vs. non-OCD) of CLZ metabolism ( p = 0.010) at pd = 0.001, which is listed in Table 3 .

Of the 764 SNPs, 98 of them were nominally significant from our data using a threshold of P < 0.01, whereas one would expect only 7.64 to be significant under the null hypothesis ( P = 7.4 × 10 –74 ).

The prevalence of FMR1 premutation carriers in the parents of the SSC cohort compared to the prevalence observed in samples from the MRGB ( Figure 3 C) were significantly higher for mothers ( p -value = 4.057 × 10 −5 ) and nominally significant for fathers ( p -value = 0.010).