“nominally significant”

All exposures showed at least nominally significant associations with increased mortality, most significantly for SBP (HR, 1.04; 95% CI, 1.03-1.06; P = 1.9 × 10 −14 ); the association of WMH with mortality was no longer significant after adjusting for educational level or interim stroke status (eTables 9 and 10 in Supplement 1 ).

Including rs74653330 (p.Ala481Thr), a missense lead variant in OCA2 , a total of 12 independent nonsynonymous variants associated with skin color traits were identified in the GWAS (Supplementary Data 5 ): 1 in a previously unreported locus, 9 in previously reported loci, and 2 in nominally significant loci (top variants of 2 loci did not pass the genome-wide significance level, P < 5.0 × 10 −8 ).

In the WHI, all but one of the 1000 cis CpG-transcript pairs from discovery in FHS replicated at a nominally significant p -value of 0.05 with matching effect directionality, while 997 replicated at p < 1E−7 with matching effect directionality.

Although they did not survive false discovery rate correction (FDR) for multiple testing (Additional file 1 : Table S3), the nominally significant pairwise comparisons showed enrichment for π c differences related to hematological and metabolic traits (hematological fold-enrichment = 4.45, p = 2.15 × 10 –7 ; metabolic fold-enrichment = 4.05, p = 4.01 × 10 –6 ).

Supplementary Materials Supplementary Table 1: nominally significant genome-wide significant findings with a P value < 1 × 10 −6 .

6, the text now reading “Numbers of SNPs that were nominally significant ( P < 1 × 10 −6 ) in the IPF GWAS meta-analysis and also eQTL” originally read “Heatmaps presenting the numbers of eQTLs that were nominally significant ( P < 1 × 10 −6 ) in the IPF GWAS meta-analysis” and has now been corrected in the HTML and PDF versions of the article.

Nominally significant associations were observed for the following health risk factors: Telomere length was longer among girls compared to boys (p = 3 e–06) and among children of high affluence families (p=0.008).

The minor alleles of the rs698195, rs3750552, and rs7275360 variants exhibited nominally significant associations with the allergic disease phenotype (rs698195: β=0.646, p =3.72×10 −6 ; rs3750552: β=1.33, p =4.40×10 −6 ; rs7275360: β=1.775, p =3.15×10 −6 ).

After overlapping the pQTL variants with the nominally significant ( P <1 × 10 -5 ) association signals of the GWAS Catalog, they identified that the CD33 protein-related SNP rs1878047 was also associated with BMI.

Cross-population transferability of loci Of the nominally significant ( p < 1 × 10 −5 ) loci in the short and long sleep duration analyses in the AFR GWAS, none reached even a nominal significance threshold of p < 0.05 in the EUR analysis, and none demonstrate a lower p-value in the cross-population analysis.

The numbers of genes or isoform-related genes having effects on eQTL, sQTL, and 3′aQTL in one or more cell conditions were 9775, 10189, and 4087, respectively (nominally significant p < 1 × 10 −5 ).

2.8 EWAS of physical activity and functional analyses At the nominally significant threshold (defined as p < 1 × 10 −5 ), we identified 7 CpGs associated with %time spent in MVPA (Figure 3a and Table S4a ), and 12 CpGs associated with MET‐Hours (Figure 3b and Table S4b ).

Considering both genders together, we observe a nominally significant increased expression of App / APP in TG mice compared to WT controls in neurons ( p value = 1.72E-05, adjusted p value = 0.33) using a Poisson generalized linear model [ 17 ].

14 , a SNP at the PIDD1 gene locus reached suggestive significance 14 ( P = 7 × 10 −7 ), and our lead novel variants at SSBP3 and THSD7A were at least nominally significant ( P = 2.61 × 10 −5 and P = 0.025, respectively).

Only the eQTL for miR-4707-3p (rs2273626) was even nominally significantly associated with expression of its host gene ( HAUS4 ; nominal P = 0.0002), indicating that most of the miR-eQTL identified in this study operate through independent mechanisms.

For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of P = 2.1 × 10 −4 .

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

Results with IVW- P < 0.05 was considered nominally significant and IVW- P < 0.00045 was taken as statistically significant. 3 Results 3.1 MR results in the discovery stage The list of 110 SRPs was in Table 1 .

However, we detected an eQTL signal tagged by rs11235459 which was nominally significant in both CSF pTau GWAS ( p = 5.4 × 10 –4 , OR = 0.93 [95% CI 0.89–0.97]) and INPPL1 ROSMAP DLPFC eQTL catalogue ( p = 9.1 × 10 –4 , beta = -0.06 [95% CI −0.02 to −0.09]) (Fig. 9 b).

Preliminary examination revealed a nominally significant relationship (B=−0.122, t=−1.91, p=0.057 −2 tailed) in this study, following a priori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity.

Preliminary examination revealed a nominally significant relationship (B = −0.122, t = −1.91, p = 0.057−2 tailed) in this study, following apriori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity (greater than four alleles predicted unspecified drug severity risk).

p value = 1.34E-04) and a nominally significant decrease in de novo PD vs. control ( p value = 9.41E-04; adj. p value = 5.86E-02), is a furan fatty acid previously suggested as a marker for fish oil intake 28 , which could indicate a diet with high levels of omega-3 fatty acids.

Nominally significant DEGs with a p -value < 0.001 were used as the input for the gene set enrichment analyses using FUMA [ 31 ] and ShinyGO version 0.77, as well as for transcription factor binding site enrichment analysis using CiiiDER [ 32 ].

Among 235 colocalizations with adipose eQTL ( 25 ), 25 (10.6%) also had a nominally significant trait-gene expression association, at an arbitrary P- value threshold of P ≤ 1e−3, despite a sample size of just 859 participants ( Supplementary Table 12 ); 80% of these had consistent effect directions.

At a nominally significant threshold of p-value ≤ 0.001, GWAS analysis discovered 148 MTAs, pointing to 54 QTLs for the coefficient of infection and 179 MTAs for agronomic traits.