Excerpts

Precise statistics, beyond qualitative indication of significance at P <0.05, are not published in the Tracking Mammals Partnership Update 33 , so any trends were conservatively allocated as marginally significant at 0.01< P <0.05.

Probability values <0.10 but >0.05 (0.10< P <0.05) were considered marginally significant, and values <0.05 ( P <0.05) were considered significant.

T/F viruses with incompletely closed Envs were also more sensitive to sCD4, although this difference did not reach statistical significance ( P = 0.05; Supplementary Fig. 3d ); and we observed a significant correlation between cold and sCD4 sensitivity ( P = 0.0005; Fig. 1f ).

In total, 115/130 GEIs were nominally significant ( p < 0.05) and directionally concordant with estimates from the replication set (Supplementary Data 13 ).

The dust-induced RF in SSP126 shows a slightly increasing trend ( p < 0.05 from the MK test) that switches to a slightly decreasing trend ( p < 0.05 from the MK test) if future dust deposition remains at the historical value (Fig.

Channels demonstrating a positive trend were identified with P < 0.05 and a Mann–Whitney Z -value that was positive, whereas channels with a negative trend were identified with P < 0.05 and a Mann–Whitney Z -value that was negative.

Nominally significant ( P < 0.05 but not meeting Bonferroni threshold P < 0.00238) included negative correlations with educational attainment and autism spectrum disorder and positive correlations with migraine, insomnia, and multiple sclerosis (Fig. 2a , and Supplementary Data 1 ).

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

3c ), and immune scores showed a trend and modest correlation with PFS (Spearman ρ = 0.35, p = 0.05; Fig. 3d ).

coli lysates expressing IsmA and SpiR revealed that SpiR generated a higher cholestenone signal, with a marginally significant difference ( U = 9.0, p = 0.05, Mann–Whitney U test).

However, in successive models of Model 3 and 4 (addition of POAG established and suspected risk factors), and Model 5 (further adjust for co-morbidities), we observed that while no metabolite exhibited significance at the NEF < 0.2 level (except for LPC(16:0) in Model 3), all were nominally significant and the direction of associations for the metabolites was similar ( p < 0.05).

We found 99.3% (5442/5478) of the FDR significant associations also had a nominally significant ( p ≤ 0.05) association in the Spearman rank test (Fig.

The Mann-Kendall method was then used to test the significance of the trend, which indicates a significant trend change when p < 0.05.

A total of 68 salt-related metabolites showed nominally significant associations with various salt-related gut-microbial species and functional pathways ( p < 0.05), indicating that the changes in gut microbiota may contribute to the changes in metabolite (Supplementary Figs. 8 and 9 ).

After filtering to the 176 clock-disease associations that were Bonferroni significant in the Cox models, there were 32 instances where the AUC improvement between the null and full model was greater than 0.01 and nominally significant at P < 0.05 (Fig. 2 and Supplementary Data 8 ).

Depending on the model type selected, between 8% and 19% of protein pairs exhibited a nominally significant correlation ( P < 0.05) between predicted and observed expression/co-expression in all three models, but this percentage rose to over 99% in well-imputed pairs.

Although this analysis did not yield any significant genes after multiple testing correction, 15 genes were nominally significant ( p < 0.05), corresponding to a 2-fold enrichment with respect to the null hypothesis (Supplementary Fig. 7c ).

When AYA patients were stratified by SIL spatiotype regardless of ICI outcome, the SIL high group showed a trend of longer OS and a near-significant longer PFS ( P = 0.0504) compared to SIL low group (Supplementary Fig. 5f, g ).

5C ; P = 0.0161, Mann–Whitney test) and a marginally non-significant difference for those in complex clusters ( P = 0.0506, Mann–Whitney test).

In addition to significantly reduced paralysis scores, the Jun11695- treated group also had significantly increased weight compared to control animals ( p = 0.001 repeated measures ANOVA), and the Jun11787- treated group also had increased weight, though it was not quite significant compared to controls ( p = 0.0508, repeated measures ANOVA) (Fig. 5b ).

However, the increase was relatively moderate and only showed a statistical trend ( p = 0.0509).

Net flow also showed a significant overall effect across respiratory-like conditions (Kruskal–Wallis test, H = 5.69, p = 0.029), with condition 1 versus 3 approaching significance ( p = 0.051), indicating a trend toward enhanced net flow with stronger respiratory modulation.

These 40 consensus modules were significantly related to cortisol stress reactivity in the discovery sample (multiple analysis of covariance (MANCOVA) Pillai's trace=0.72, F(40,37)=2.4, P =0.004) and borderline significant in the cross-tissue replication sample (MANCOVA Pillai's trace=0.21, F(40,212)=1.4, P =0.051).

Moreover, αGITR treatment, along with Treg cell depletion, also showed a trend ( p = 0.051) toward prolonged survival of GBM-bearing mice over Treg cell depletion alone (Supplementary Fig. 9b ).

At the same time, dHPC - neurons showed only a trend towards significance using t -statistics ( P = 0.051, Welch’s t -test; Fig. 4e, f ) that reached significance using estimation statistics (Supplementary Fig. 5p ).