“did not reach statistical significance”

NC comparison, a clear trend was observed, even though it did not reach statistical significance as in 14 .

We rather saw a slight trend towards a decrease in cAMP release in stretched Cav3KO trabeculae after both β 1 AR and β 2 AR stimulation, though this trend did not reach statistical significance.

The mCAF1 programme exhibited an increasing trend across stages I–IV, though this did not reach statistical significance.

Furthermore, while HUVEC overexpressing EPLIN-α showed a trend towards increased transmigration compared to knockout (KO) cells, this difference did not reach statistical significance (Fig. 6 C).

While IL-13 levels showed a trend towards being higher in the older age group, this difference did not reach statistical significance Figure S1 B.

Although the fresh-to-dry ratio displayed a negative trend, it did not reach statistical significance, indicating that dry matter accumulation efficiency is governed by other regulatory pathways.

Similarly, there was an observed trend indicating that patients with PA with posttreatment PRA levels between 1 and 2 ng/mL per hour had a lower incidence of MACE compared with those with PRA levels either <1 ng/mL per hour or >2 ng/mL per hour; however, this trend also did not reach statistical significance.

30 Not all published literature supports the superiority of central (and axillary) cannulation in terms of neurologic events; some studies have found no superiority of any cannulation site, 31 and a most recent meta-analysis from the Pittsburgh group in more than 14,000 patients showed a trend toward improved outcomes with central cannulation, which did not reach statistical significance. 32 Vascular and Access Site–Related Complications Arterial cannulation for CPB involves manipulation of large vessels, which bears the risk of vascular complications such as iatrogenic (retrograde) dissection, bleeding, pseudoaneurysms, and formation of hematoma.

A clear trend toward increased CEBPB mRNA m6A‐levels upon FTO knockdown was observed that did not reach statistical significance because of high experimental variation (Fig. 8G ).

However, only two studies reported OS outcomes, which showed a trend toward benefit but did not reach statistical significance (HR=0.80, 95% CI=0.58–1.11; Figure 4D ).

Compared with the NS‐Ctrl group, the NS‐Igf2 group also showed a trend toward improvement in both the long‐term MWM test and the 7‐day CFC test, though the differences did not reach statistical significance.

Surgical incision, often necessary for complex extractions, showed a trend toward association with intraoperative hypertension in our study, although the result did not reach statistical significance ( P = 0.068).

Comparison of preoperative and postoperative FSH levels showed a trend toward increased postoperative FSH values across all three groups; however, this increase did not reach statistical significance (p=0.092) ( Figure 2 ).

In the PLN ≤8 subgroup, survival analysis showed a trend toward better survival in patients who received RAI, although this did not reach statistical significance (HR 0.70, 95% CI 0.43–1.13, P =0.142).

However, this finding did not reach statistical significance (p=0.06), suggesting that while there may be a positive trend, further studies with larger sample sizes are needed to establish a definitive effect.

Interestingly, although the increase in I Ca at 12 months did not reach statistical significance in WT chromaffin cells, a clear trend was observed.

Heterozygous Tcf4 +/(CTG)100 mice showed a trend toward increased guttae formation compared to wild-type controls, though these differences did not reach statistical significance at any time point (20 weeks: 0.114% ± 0.082% vs. 0.053% ± 0.047%, P = 0.220; 40 weeks: 0.214% ± 0.118% vs. 0.105% ± 0.065%, P = 0.184; 60 weeks: 0.314% ± 0.145% vs. 0.170% ± 0.089%, P = 0.264).

27 , 28 , 29 , 30 In this study, a higher chance of recurrence was demonstrated in patients who exhibited co-localization of PD-1/PD-L1 > 3.3%, although this value did not reach statistical significance; nevertheless, we observed a statistical trend.

Meta-analysis for diabetes DTx showed a trend toward improved hemoglobin A 1c levels in digital intervention groups compared to controls (SMD −0.96, 95% CI −2.03 to 0.11) but did not reach statistical significance ( I 2=97%).

Primary tumor location did not reach statistical significance in the multivariate model (OR = 4.607 for left-sided tumors, 95% CI: 0.854–24.855; p = 0.076), but it was retained due to potential clinical relevance, small sample size, and a p -value approaching significance.

The results showed a trend towards better active-rest rhythms in the group receiving blue light therapy, but the results did not reach statistical significance.

Numerical improvements in the LIPUS group suggest reduced ischemia, but the p-values did not reach statistical significance or were of borderline significance.

Analysis of bacterial CFUs recovered from the lung and spleen of neutropenic mice at 24 hours after infection showed a trend toward reduction in CFUs recovered for mice treated with the polymyxins COL (2.4 and 4.5 log CFU/g) and PMB (3.1 and 3.5 log CFU/g) compared with the PBS control (3.7 and 5.2 log CFU/g) ( Figure 4C ), but these differences did not reach statistical significance.

Histologic examination of hematoxylin and eosin (H&E)-stained liver sections revealed a slight trend towards reduced macrosteatosis, inflammation, and nonalcoholic fatty liver disease (NAFLD) activity score, but these did not reach statistical significance ( Figure 2 J–K ).

While overall survival (OS) in the high-expression group also showed a trend toward worse outcomes compared to the low-expression group, this difference did not reach statistical significance ( Fig. 2 i).